Colour management profile woes

Specs in sig, Windows 8.1 Pro x64.

Basically, I have a custom colour profile calibrated from mythlogic. It's a little brown I suppose, but it's a lot less harsh on the eyes and I've come to find that I much prefer its colours and softness. My problem is that sometimes when I fullscreen a game and then exit it, it will force the colour back to Windows' default calibration. The problem side to this is that I seem to be incapable of re-applying the profile afterward. I was able to do it once before, but I seem to have either forgotten how or the method no longer works. Does anyone know what I should do to fix this issue? I thoroughly dislike restarting my system just to have it happen again the next fullscreen game I run, for example.